Protein Modification Reagents
Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | MFCD30458046 | 99.0% | 427.47 g/mol | C21H21N3O5S | 5 MG
Sulfo DBCO-amine is a water-soluble click-chemistry reagent containing a dibenzocyclooctyne (DBCO) moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for efficient, copper-free bioconjugation. It is commonly used as a linker or building block in PROTAC synthesis and other bioconjugation workflows, and is supplied in small quantities for research use.
- Enables copper-free SPAAC bioconjugation.
- Water-soluble sulfonate improves aqueous compatibility.
- Contains a reactive amine for stable amide coupling.
- High purity suitable for research-grade applications.
- Available in small quantities for exploratory synthesis.
![eMolecules Broadpharm / 4-Azide-TFP-Amide-PEG4-acid / 50mg / 563055131 / BP-23989 / 98.000 / 2566404-74-6 / [null] / 482.389 / C18H22F4N4O7](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502476191.JPG-250.jpg)
eMolecules Broadpharm / 4-Azide-TFP-Amide-PEG4-acid / 50mg / 563055131 / BP-23989 / 98.000 / 2566404-74-6 / [null] / 482.389 / C18H22F4N4O7
Broadpharm / 4-Azide-TFP-Amide-PEG4-acid / 50mg / 563055131 / BP-23989 / 98.000 / 2566404-74-6 / [null] / 482.389 / C18H22F4N4O7
STA PHARMACEUTICAL US LLC FmocNH-PEG8-CH2CH2COOH | 25 g | CAS 756526-02-0 | MDL MFCD11041143
FmocNH-PEG8-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 756526-02-0
- MDL: MFCD11041143
- InChIKey: VYXGUCLTEWCVRY-UHFFFAOYSA-N
- Molecular Weight: 663.761
- Molecular Formula: C34H49NO12
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC Mal-amido-PEG12-NHS ester | 2101722-60-3 | 98.52% | C38H63N3O19 | 50 MG
Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These PROTACs are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC Amino-PEG4-GGFG-Dxd | 2879227-88-8 | 1088.14 g·mol⁻1 | C53H66FN9O15 | 5 MG
Amino-PEG4-GGFG-Dxd is a drug-linker conjugate intended for use in antibody-drug conjugate (ADC) synthesis. It couples a DXd (deruxtecan) payload to a GGFG peptide-based linker via a PEG4 spacer and provides an amino functional handle for conjugation to antibodies.
- drug-linker conjugate for ADC synthesis
- contains a DXd payload linked via a cleavable GGFG peptide linker
- includes a PEG4 spacer to improve solubility and spacing
- features an amino functional handle for conjugation chemistry
- available in small milligram quantities for research use
- molecular weight 1088.14 g·mol⁻1, formula C53H66FN9O15
Broadpharm Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
Azido-PEG5-Val-Cit-PAB-OH, 500 mg, 98% purity, Cleavable linker, Enzymatic cleavage with Val-Cit, Azide reactive group
Medchemexpress LLC Mal-PEG4-Val-Cit-PAB-OH | 2055041-39-7 | MFCD29918232 | 96.9% | 706.78 g/mol | C33H50N6O11 | 50 MG
Mal-PEG4-Val-Cit-PAB-OH is a cleavable four-unit polyethylene glycol (PEG) linker used to connect an antibody and a cytotoxic payload in antibody-drug conjugate (ADC) synthesis. It contains a maleimide reactive group for thiol coupling, a PEG4 spacer, a Val-Cit protease-cleavable dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer that enables intracellular release of payloads.
- Cleavable four-unit PEG linker enabling protease-mediated release.
- Maleimide functional group for thiol conjugation.
- Val-Cit dipeptide designed for cathepsin B cleavage.
- PAB self-immolative spacer to promote efficient payload release.
- Suitable for ADC synthesis and bioconjugation workflows.
Medchemexpress LLC NH2-C5-PEG4-N3-L-lysine-PEG3-N3 | 99.4% | 619.71 | C25H49N9O9 | 50 MG
NH2-C5-PEG4-N3-L-lysine-PEG3-N3 is a cleavable 7-unit PEG antibody-drug conjugate (ADC) linker containing an azide functional group, intended for research use in click chemistry conjugations. It facilitates attachment of payloads to biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC).
- Cleavable 7-unit PEG linker suitable for ADC synthesis.
- Azide functional group for CuAAC and SPAAC click reactions.
- High purity (≈99.4%).
- Water soluble: ≥100 mg/mL.
- Appearance: colorless to light yellow liquid.
- Recommended storage: pure form at -20°C.
- Packaged in 50 mg units.
Medchemexpress LLC N3-PEG11-CH2CH2Br | 2098982-00-2 | MFCD32696701 | 99.8% | 634.56 g/mol | C24H48BrN3O11 | 50 MG
N3-PEG11-CH2CH2Br is a polyethylene glycol (PEG11) linker with an azide (N3) terminus and a bromide-functionalized ethylene spacer. It is a hydrophilic, viscous liquid used in bioconjugation and click-chemistry workflows to improve aqueous solubility and provide a reactive bromide handle for further modification.
- Azide-terminated PEG11 linker for click chemistry.
- Bromide-functionalized ethylene spacer provides a reactive handle.
- Hydrophilic PEG spacer increases solubility in aqueous media.
- High purity suitable for research applications.
- Recommended storage conditions maintain stability.
Medchemexpress LLC Amino-PEG4-DOTA | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 5mg
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
Medchemexpress LLC N3-PEG4-C2-NHS ester | 944251-24-5 | MFCD13184948 | >90% | 388.37 g/mol | C15H24N4O8 | 50 MG
N3-PEG4-C2-NHS ester is an azide-functionalized, non-cleavable polyethylene glycol (PEG) linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and an azide (N3) group for click chemistry applications such as antibody-drug conjugate (ADC) synthesis and bioconjugation.
- Azide-functionalized 4-unit PEG linker suitable for bioconjugation.
- N-hydroxysuccinimide (NHS) ester for efficient amine coupling.
- Compatible with copper-catalyzed and strain-promoted azide-alkyne cycloaddition.
- High solubility in DMSO; stock solutions commonly prepared per datasheet guidance.
- Storage recommendations: pure form -20°C up to 3 years; in solvent -80°C for 6 months or -20°C for 1 month.
Medchemexpress LLC Tos-PEG4-THP | 86259-89-4 | 100 MG
Tos-PEG4-THP is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTAC K-Ras Degrader-1. PROTACs are compounds containing two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a specific protein. These compounds leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Composed of two ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- The other ligand targets a specific protein
- Utilizes the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC m-PEG15-NHS ester | 98.0% | 50 MG
m-PEG15-NHS ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
Medchemexpress LLC Propargyl-PEG3-CH2COOH | 1694731-93-5 | 100 MG
Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Functions as a PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups